(1) Fibrinolytic Effect
(2) Reduction in Hypertension
Kim, J. et al. Effects of NSK-SD (nattokinase) on blood pressure: A randomized controlled trial. ISSN 0916-9636. Vol. 31, No. 8, August 2008, Hypertension Research.
(3) Decrease in Blood Viscosity
Pais, E., Alexy, T., Holsworth, R.E., and Meislman, H.J., 2006. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin. Hemorheol. Microcirc. 35: 139-142.
(4) Antiplatelet Aggregating Activity
Takaoka, S., Murata, Y., Moriyama, H. and Hoshi, K. The 123rd Annual Meeting of the Pharmaceutical Society of Japan, Tokyo, Japan. Nagasaki, Antiplatelet effects of nattokinase (NSK-SD), p.134.
(5) Improving Effect on Blood Flow
Iuchi, S., Dokai, H. and Shionoya, K. Improvement of blood flow increase by ingestion of NSK II. FOOD Style 21, Vol. 10, No. 8, 78-90 (2006).
(6) Reduction in Plasminogen Activator Inhibitor type 1 (PAI-1)
Urano, T., Ihara, H., Suzuki, Y., Oike, M., Akita, S., Tsukamoto. Y., Suzuki, I., and Takada, A., 2001. The pro-fibrinolytic enzyme Subtilisin NAT purified from Bacillus subtilis cleaves and inactivates plasminogen activator inhibitor. J. Bio. Chem. 276: 24690-24696.